- Iza Calzado was born on 12 August 1982 in Quezon City, Philippines.
- Her birth name is Maria Izadora Ussher Calzado.
- Her father is the reknowned choreographer and TV director, Lito Calzado and her mother was the late Mary Ann "Antonia" Ussher who was a Spanish-Filipina ancestry. Her father married her stepmother Myrna after the latter passed away.
- She has a brother named Dash who is a member of a Filipino rap group, Legit Misfitz.
- Iza Calzado spent her elementary days at School of the Holy Spirit; her high school years in Miriam College; and took up an undergraduate degree in Fine Arts at the University of Santo Tomas.
- Iza Calzado was a voice dubber for the Venezuelan telenovela, "Mis 3 Hermanas" known as "All My Love" in the Philippines, before she became known in the movie industry.
- Iza Calzado starred in her first soap opera, "Te Amo, Maging Sino Ka Man" with Argentinean actor, Segundo Cernadas, as her partner.
- In 2010, Iza Calzado made her first two-piece bikini TV appearance in the TV series, "Beauty Queen" with TJ Trinidad as her leading man.
- Her first TV comedy show was in GMA's "I Heart You, Pare!" and her last appearance in GMA was in the TV sitcom, "Andres de Saya". She was in GMA from 2001 to 2011.
- She appeared in her first TV drama series in ABS-CBN's "Kahit Puso'y Masugatan". She is currently an ABS-CBN contract star which started on 2012.
- She won her first "Best Supporting Actress" award from the 28th Gawad Urian Awards in 2004 for her role in the movie "Milan" with a total of 11 wins and 13 nominations showing her prowess as an actress.
- The 2017 movie "Bliss" was her first ever X-rated film as reviewed by the MTRCB.